| Characteristics | Details |
|---|---|
| Generic Name | Prochlorperazine |
| Dosage Form | Tablet |
| Strengths Available | 5 mg, 10 mg |
| Indications | Nausea, Vomiting, Schizophrenia |
| Administration Route | Oral |
| Learn More About Compazine | |
Pharmacokinetics
Compazine, also known as prochlorperazine, is an antipsychotic used primarily for controlling severe nausea and vomiting. The pharmacokinetics of prochlorperazine reveal it undergoes extensive first-pass metabolism in the liver. This limits its systemic bioavailability. Absorption is rapid but not complete. The plasma protein binding is high, which leads to a distribution half-life that lasts for several hours.
Prochlorperazine is extensively metabolized in the liver, and only a small fraction is excreted unchanged. The metabolic pathway involves hydroxylation and conjugation. Elimination occurs primarily through the kidneys and, to a lesser extent, feces. The half-life varies but typically ranges from 4 to 8 hours. Due to the hepatic metabolism, liver function may significantly impact the clearance of the drug.
Correct Use
Administer Compazine with caution, particularly when treating nausea and vomiting. Dosage varies based on indication. Tablets are taken orally, with or without food. The 5 mg or 10 mg tablets should be swallowed whole, not crushed or chewed. Frequency depends on the clinical condition and response to treatment.
Patients should adhere to prescribed dosing schedules. Healthcare providers must tailor therapy to individual needs. Adverse effects might necessitate dosage adjustments. Compazine must be used cautiously in patients with cardiovascular disorders due to its potential to prolong the QT interval.
Warnings & Precautions
Serious adverse reactions may include extrapyramidal symptoms, tardive dyskinesia, and neuroleptic malignant syndrome. Compazine is contraindicated in patients with hypersensitivity to prochlorperazine. Caution is advised for elderly patients, especially those with dementia-related psychosis, due to an increased risk of mortality.
Patients should be monitored for orthostatic hypotension, especially when initiating treatment. Alcohol and other CNS depressants may enhance sedation effects. The use in pregnant or breastfeeding women requires careful consideration of potential risks and benefits.
Missed Dose
If a dose of Compazine is missed, it should be taken as soon as remembered. If it is close to the next scheduled dose, skip the missed dose. Do not double doses to compensate for a missed one. Consistent adherence to dosing schedule ensures optimal therapeutic outcomes.
For patients on a multiple daily dose regimen, maintaining a regular schedule is key. Contact a healthcare provider if multiple doses are missed, as this might necessitate a reevaluation of the treatment regimen.
Toxicity
Overdose of Compazine may lead to symptoms such as severe drowsiness, dizziness, or convulsions. Immediate medical attention is required. Toxicity often results from excess central nervous system depression. Treatment is primarily supportive and symptomatic.
Activated charcoal may be considered if ingestion is recent. Due to the risk of prolonged QT interval, cardiac monitoring is recommended. There is no specific antidote for Compazine overdose, thus management focuses on maintaining vital functions.
Purchase Compazine Without Prescription
Purchasing Compazine without a prescription is not recommended due to the necessity of professional medical guidance. Proper assessment by a healthcare provider is crucial for ensuring safe and effective use. Dosage and treatment duration should always align with medical advice.
Patients should seek guidance from licensed pharmacies and avoid unauthorized sellers. This ensures product authenticity and compliance with regulatory standards. Always verify the source before acquisition to safeguard health and well-being.
| Adverse Effect | Frequency | Management |
|---|---|---|
| Drowsiness | Common | Dose adjustment |
| Extrapyramidal Symptoms | Uncommon | Anticholinergic agents |
| Orthostatic Hypotension | Rare | Monitor BP |
Information taken from:
- https://corazonadafilms.com/2023/12/16/vacunacion-contra-el-herpes-zoster-en-el-contexto-del-tratamiento-antiplaquetario/
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- https://spectradubai.com/impact-of-baclofen-injections-in-patients-with-smallpox/
- https://texiri.com/malaria-pharmacological-insights-and-applications/
- https://www.depannage-vitrier-besancon.fr/syndrome-du-qt-long-etude-de-lefficacite-de-la-fosphenytoine/